New Published Study Supporting Xanthigen®'s Mechanism of Action in Exerting Weight Loss

New Published Study Supporting Xanthigen®’s Mechanism of Action in Exerting Weight Loss

PL Thomas and Polinat have announced that a recent paper elaborating the mechanism of Xanthigen® has been published in a peer-review journal in January 2012 (J Agric Food Chem 2012 Jan 3). This research supports the 2010 published peer-review clinical paper describing the role of Xanthigen® in weight management (Diabetes, Obesity, and Metabolism 12:72-8, 2010).

Xanthigen® is a patent-pending composition standardized to two synergistic anti-obesity compounds, fucoxanthin (from brown sea weed) and punicic acid (a unique gamma-linolenic acid from pomegranate seed oil). The 2010 published 16-week, double-blind, randomized, placebo controlled study with non-diabetic, obese patients showed that Xanthigen® lowered  liver fat, body weight, and improved liver markers in volunteers with non-alcoholic fatty liver disease (NAFLD).  The molecular basis of the clinical findings was further investigated in  the in vitro study.

The January 2012 published paper is based on an in vitro study conducted by National Kaohsiung Marine University, Taiwan, in cooperation with Rutgers University, NJ. The study shows that Xanthigen® may work by preventing build-up of adipose (fatty) tissue, suppressing  differentiation of preadipocytes (immature fat cells) into adipocytes (mature fat cells), encouraging lipogenesis (fat synthesis) and ultimately suppressing adipogenesis (fatty tissue build-up).

“These results indicate that Xanthigen® may suppress fatty tissue build-up through multiple mechanisms and may have further explained applications for this dietary supplement in improving liver functions and managing obesity,” explains Vladimir Badmaev, MD, PhD, director of scientific and medical affairs for PL Thomas and Polinat. “One of the interesting aspects of the reported mechanism is activation of the Sirt1 gene expression (Sirt1 is sometimes referred to as ‘youth factor’) in the mature fat cells.  Obesity, overweight status and aging tend to decrease Sirt-1  gene expression in the body and fat cells, whereas slimming and improving body composition upregulates Sirt-1 gene expression almost in a manner that restores the body’s youthful weight and body composition.”

The Sirt1 activation finding in research on Xanthigen® is an original discovery providing basis for Xanthigen® patent application. Xanthigen® is available through PL Thomas.


About Polifenoles Naturales
Polinat, located in the city of Las Palmas on Gran Canaria Island, Spain, is committed to applying the best science and extraction innovations to provide the highest quality, scientifically validated botanical extractions to a broad client base.

About P.L.Thomas
PL Thomas, a long-time participant in the food and dietary supplement industries, is a health and wellness company focused on providing clients and consumers with clinically supported, natural ingredients and “cleaner” labels.

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