Plasma Concentrations of Boswellic Acids in Fasting Healthy Humans Supplemented with a Water-Soluble BSE vs. Reference BSE

Plasma Concentrations of Boswellic Acids in Fasting Healthy Humans Supplemented with a Water-Soluble Boswellia Extract (78% AKBA) vs. Reference Boswellia Extract (30% AKBA)

Davis, Barbara & Sengupta, Krishanu & Alluri, Venkata & Golakoti, Trimurtulu.

(2019) CURRENT DEVELOPMENTS IN NUTRITION. 3. 10.1093/cdn/nzz031.P06-005-19.

Objectives: A randomized, open label, balanced, two-way crossover study compared the oral bioavailability and pharmacokinetic profiles of two Boswellia products standardized to 3-O-acetyl-11-Keto-β-boswellic acid (AKBA).

Methods: Twenty-two fasted male participants completed the study. They received a single oral-dose of water-soluble Boswellia extract 78% (LI51202F1) or to the standard Boswellia extract 30% (5-Loxin) at 30 mg AKBA equivalent with 240 mL water on 2 separate occasions 12 days apart. Plasma AKBA and KBA were analyzed using a LC-MS/MS in pre- (0 hours) and post-dose (0.5, 1, 1.5, 2, 2.5, 3, 4, 8, 12 and 24 hours) blood samples. Pharmacokinetic analysis was performed using WinNonlin® version 7.0 (Pharsight Corporation, USA).

Results: Comparative analysis of the pharmacokinetic parameters showed LI51202F1 had higher (111.11%) Cmax for AKBA vs. 5-Loxin. The bioavailability indicated by Geometric means of AUC0-t and AUC0-∞ were 25.49 % and 16.13% higher in LI51202F1 than 5-Loxin.

Conclusions: The present study demonstrates that oral ingestion of water soluble and standard Boswellia extracts resulted in similar bioavailability of AKBA. Interestingly, the water-soluble version exhibited higher Cmax and AUC values, which could be attributed to the improved solubility of LI51202F1.