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Zembrin is the world’s first patented, standardized and clinically studied extract of a natural cultivar of Sceletium tortuosum. Sceletium, known by the San people of South Africa as “Kanna,” has been used for millennia for its stress-relieving and mood-enhancing effects. Zembrin is standardized to a unique fingerprint that is the subject of multiple clinical trials, an extensive peer-reviewed safety portfolio and a multi-patent portfolio.

Facts About Zembrin

  • Experiential (feel the benefits)
  • Fast-acting
  • Clinically-studied
  • Extensive safety testing
  • Multi-Patented
  • Seed-to-shelf quality control
  • Non-GMO
  • Ethically-sourced

Zembrin is Great for Multiple Market Segments

Stress and anxiety are unavoidable features of modern life. It has been shown to affect not only our sense of well-being, but how we perform at work and at play. As a stand-alone ingredient, or as a differentiating part of a formulation, Zembrin adds an element that can take your formulation to the next level.


Zembrin is Clinically Studied

Zembrin has an active clinical program with multiple studies, including a recent innovative trial using functional Magnetic Resonance Imaging (fMRI) technology to study the effects of acute supplementation on the “threat circuitry” of the human brain. The double-blind placebo-controlled crossover trial showed that 25 mg Zembrin reduced anxiety-related activity of the amygdala and its associated anxiety circuitry within 2 hours of administration. These results provide the first evidence for brain areas where Zembrin acts, and confirmation of the potential for Zembrin to help in the management of stress.  A recent U.S. patent protects the dual mechanism of 5-HT and PDE4 inhibition and the application of mesembrenone as a PDE4 inhibitor.


Zembrin is Ethically-Sourced

Zembrin was awarded the first ever Export and Bioprospecting permit to be issued by the South African government, #001. Zembrin is the impetus for Africa’s first prior-informed consent benefit-sharing agreement, signed with the South African San Council after 2 years of negotiation, to formally recognize the primary indigenous knowledge holders of Sceletium.

Zembrin is a Unique Ingredient

Zembrin represents the application of cutting edge neuro-science research and agritech to a traditional plant to create a fast-acting, safe, effective and experiential stress-relieving ingredient. The Zembrin story is a shining example of ethical innovation.


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