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    Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

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    Seth Flowerman
    President and CEO

AprèsFlex® 5-Day Joint Support

Mobility is Life
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OVERVIEW

AprèsFlex® is one of the world’s best-selling joint health ingredients – with multiple clinical studies that demonstrate efficacy starting at 5 days – with a low dose.

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5 Days

AprèsFlex has been shown in clinical trials to improve joint comfort in as little as 5 days.

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100mg

Proven efficacy at only 100mg/day.

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11 Studies

The science behind AprèsFlex is solid. It is supported by 7 preclinical and 4 human clinical trials.

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6 Months

AprèsFlex has been clinically shown to continuously improve joint comfort and function at six months.

FEATURES & BENEFITS

 

Low, 100mg/day dose

Fast acting joint comfort in just 5 days*

56% reduction in WOMAC pain scores at 30 days*

70% reduction in WOMAC pain scores at 6 months*

Improved knee joint space and reduction of cartilage degradation*

Preservation of cartilage and improved cartilage health*

Four double-blind clinical trials

Sustainable, botanical ingredient

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CERTIFICATIONS

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VEGAN

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GLUTEN-FREE

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NON-GMO

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HALAL

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KOSHER

A Patented, Synergistic Extract of Boswellia serrata

In joint health products, AprèsFlex is powering some of the best-known joint health consumer brands in the world.

Boswellia serrata

Sourced from the forests of India, Boswellia has been used in Ayurvedic medicine for thousands of years.

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A Sacred Tree

Boswellia serrata are considered sacred by Indian families and given as gifts at weddings.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

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Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

RESEARCH

One of the most clinically studied mobility support ingredients on the market

AprèsFlex 5-Day Joint Support has been the subject of extensive preclinical and clinical research to demonstrate its mechanisms of action and efficacy in supporting joint comfort and mobility.

In its third clinical study, AprèsFlex was found to:


• Provide significant reduction (p<0.05) in all pain scores at five days compared to the placebo*


• Provide significant improvement (p<0.05) in all function scores at five days compared to placebo*

 

Visual Analog Score (VAS) (Graph A)
Lequesne Index (LFI) (Graph B)
WOMAC Index ((Graphs C, D, E)

Long-Term Performance

In its fourth clinical trial, at six months, AprèsFlex was found to:

• Improve joint comfort by 70%*

• Reduce stiffness by 72%*

• Enhance physical function*

• Improve walking speed by 27%*

Cartilage Preservation and Protection

In its fourth clinical trial, AprèsFlex was found to:

Mitigate loss of joint space compared to placebo*

Preserve cartilage thickness*

Reduce markers of cartilage breakdown*

(^p<0.05 vs placebo)
For more information on AprèsFlex science, see the Resources section below.

SEE OUR CLINICAL STUDIES

Clinical Study: AprèsFlex improves joint comfort and function at 5 days

ApresFlex improves joint comfort and function chart with image

AprèsFlex was found to: provide significant reduction (p<0.05) in all pain scores at five days  and to provide significant improvement(p<0.05) in all function scores at five days compared to placebo.
* Karlapudi V, Sunkara KB, Konda PR, Sarma KV, Rokkam MP. Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Short-Term 30-Day Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Am Nutr Assoc. 2023;42(2):159-168. doi:10.1080/07315724.2021.2014370

 

GET THE RESULTS

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Clinical Study: Long-term study shows increasing joint comfort and cartilage preservation

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Eighty normal-to-overweight women and men (age 40-75) received either 100 mg/day of AprèsFlex or a matching placebo for six months. Subjects taking AprèsFlex experienced steady improvement in joint comfort and function with up to a 70% reduction in pain and a 72% reduction in stiffness by the end of the study. MRI assessments of joint space in the knee showed AprèsFlex limited joint space narrowing. MRIs of femoral, patellar, lateral tibial, and medial tibial cartilage thickness showed decreases in the placebo group over six months, whereas cartilage thickness was maintained and even slightly improved in the AprèsFlex group at 180 days. (Publication pending)

 

GET THE RESULTS

ApresFlex Femoral Cartilage Thickness chart with image
ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

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Bone, Joint & Muscle Health

With AprèsFlex, you can make any joint health product work faster and better starting at 5 days – with a low dose.

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Healthy Aging

Today’s seniors travel more, play more and do more than ever. AprèsFlex can help them get moving and keep moving.

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Active/Sports Nutrition

Inflammation from exercise has similarities to that which occurs with the aging process.

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Weight Management

Mobility and freedom from discomfort are critical to the kind of exercise we need to maintain a healthy weight.

APPLICATIONS

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CAPSULES

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EFFERVESCENTS

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POWDERS

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SOFT GELS

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STICK PACKS

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TABLETS

ORIGIN STORY

It Starts with Boswellia

Boswellia serrata, native to India, is one of 19 species of the genus Boswellia. PLT Boswellia-based ingredients are sourced only from select regions of India.

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A Storied Past

The plant resin of the Boswellia tree provides a commercial oil known as frankincense, which has a “woody, spicy and haunting smell.” It is possibly best known through the biblical story of the Three Wise Men, who delivered gifts of gold, frankincense, and myrrh.

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Careful Harvesting

The harvest of Boswellia oleo gum resin occurs through “wounding and healing” of the tree, termed “tapping,” shallow debarking the tree to expose resin glands and stimulate resin production. Harvest is stopped from May through October or November in order to allow a period for tree recovery.

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Exacting Analytics

Boswellia serrata oleo gum resin extracts are evaluated for unique characteristic features. Laila Nutraceuticals has developed an identification method using fingerprint profiles and high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC).

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State-of-the-Art Processing

Laila Nutraceuticals facilities maintain third-party Good Manufacturing Practices (GMP) certification from NSF International. The NSF certification includes compliance to the U.S. FDA Food Safety Modernization Act (FSMA) and cGMP 21 CFR 117 + 21 CFR 111.

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QUALITY

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From Harvest to Finished Ingredient


The starting point for 5-LOXIN – Boswellia serrata – is a plant that produces Indian frankincense. It is also known as Indian olibanum, Salai guggul, and Sallaki in Sanskrit. The plant is native to much of India and the Punjab region that extends into Pakistan. In partnership with Laila, PLT is committed to the safety and fair treatment of the people who harvest 5-LOXIN. We want to support the long-term health and well-being of the tribal culture and the natural environment upon which it relies.

Every batch of the 5-LOXIN harvest is assigned a specific batch number, and each batch of finished product is traced to a specific region and set of trees. 5-LOXIN is tested and must comply with predefined specifications for different parameters at different stages of product manufacturing – from raw materials to finished product. Quality is monitored by a multi-disciplinary organization with dedicated departments for taxonomy (botanical Identification), raw material analysis, chemical analysis, microbiology, and more.

SUSTAINABILITY

Understanding the Difference Makes the Difference


During the fourth quarter of 2021, PLT Health Solutions announced the commencement of a third-party sustainability audit program on Boswellia serrata trees, which serve as the raw material source for some of our most important ingredients. The audit of this India resource was conducted by renowned botanical research consultancy Botanical Liaisons, LLC, and was undertaken to help the nutraceutical industry and non-governmental agencies around the world understand what we and our ingredient innovation partner Laila Nutraceuticals have known for many years: proper stewardship of natural resources and social responsibility toward the communities that support our work are both the right thing to do and good business.


The audit program was a step in PLT’s campaign to document the sustainability of the tree resource. PLT’s Chairman, Paul Flowerman, made field trips to the key production areas in 2018 and 2019 to observe and document the variety of tree populations, methods of natural and forced propagation and the status of the tribal groups involved in the care of the trees and resin production.

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A third audit program was based on a broad range of environmental, cultural and economic parameters. In March 2022 Botanical Liaisons reported to PLT its preliminary conclusions, which included this statement: “It is clear from the information collected from the stakeholders that [sustainability] is supported. Boswellia serrata has several sustainability advantages that prevent over-harvesting of PLT-sourced Boswellia compared to other sources and species of Boswellia.” The report recommended a series of next steps to further evaluate and promote sustainability. 


Subsequently, four important additional developments have added considerable strength to the Boswellia serrata sustainability story:

  1. Authoritative tree survey data from Madhya Pradesh quantified the robustness and sufficiency of the tree resource to provide present and future resin requirements.
  2. CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) determined during its November 2022 meeting (COP 19 in Panama City) that no Boswellia species would get added to the CITES Appendix lists. The health of Boswellia serrata, the only species of commercial importance for PLT, was documented, including information about the replenishment of the resource.
  3. AHPA (American Herbal Products Association) convened an expert panel, which has drafted a brochure entitled, “Good Stewardship Harvesting of Boswellia (Boswellia Serrata).” This is a definitive presentation of current best practices.
  4. An important study modeling the impact of significant climate change by 2050 on Boswellia serrata resources predicted that almost all of Madhya Pradesh, the source of 90+% of commercial resin, will remain conducive for a healthy tree population.

These initiatives represent the type of work we do with our PLT360™ initiative. Introduced in 2015, our PLT360 initiative is a business-wide commitment by PLT Health Solutions to develop ingredients that our customers can be confident and proud to supply to their own customers – knowing that these ingredients are safe, of high quality, efficacious and harvested and manufactured sustainably. PLT360 examines every business decision and business process we undertake to be transparent with our operations, build trust with the health & well-being community and, together with them, support healthier, happier lives for the consumers we serve. 

INSIGHTS

Flexibility is Freedom


When we play a round of golf, spend an afternoon on our knees in the garden or just take a long walk, we celebrate our freedom.


AprèsFlex has been giving people back their freedom for almost a decade by delivering joint comfort and flexibility from a 100 mg dose that starts to work in only 5 days.


At PLT, we are working on the concept of Mobility Solutions – which includes benefits for joints, muscle and cartilage. We’re thinking about athletes who want to perform better and recover faster. We’re thinking about people with physically demanding jobs who don’t want to or can’t take a day off. We’re thinking about anyone who has an active lifestyle and wants to embrace it despite the rigors. And yes, we’re thinking about the global aging population.


PLT Health Solutions’ leading portfolio of mobility support ingredients – based on more than a decade of ongoing research – has been developed to help you deliver innovative products that can capture the attention and the trust of consumers. All our ingredients are backed by multiple clinical studies – and offer rapid improvements from a low dose – in just about any delivery system you can imagine.


Around the world, people have turned to AprèsFlex more than a billion times as a drug-free approach to joint comfort. They trust the science. Trust the quality. And trust the experience.

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“We worship and protect these trees and this tradition is also passed on from generation to generation.”

Collector in Madhya Pradesh

RESOURCES

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ApresFlex® Product Sheet
April 19, 2022
Behind every ingredient solution is an even better story, download the product sheet to learn more.
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PLT Health Solutions Granted Broad Ranging Joint Health and Cartilage Claims from Health Canada Based on Clinical Study Results
August 26, 2024

AprèsFlex® 5-Day Joint Support Has Been Clinically Demonstrated to Improve Joint Comfort, Flexibility and Function as well as to Provide Ground-Breaking Cartilage Preservation and Protection

Industry NewsPress Releases
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PLT Announces New Clinical Study on AprèsFlex® 5-Day Joint Support Ingredient that Confirms Fast-Acting Efficacy from 100 mg/Day Dose
July 20, 2022
Patented Boswellia serrata complex improves joint comfort and enhances and improves joint function
Industry NewsPress Releases
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New Publication on Boswellia serrata Ingredients Finds that AprèsFlex® 5-Day Joint Support is Most Efficacious
May 28, 2024

Systematic Review and Sub-group Meta-analysis Reviewed Nine Ingredients for Efficacy in Pain, Stiffness and Functionality

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Nutraceutical Business Review: “PLT announces new clinical study on AprèsFlex 5-Day Joint Support ingredient that confirms fast-acting efficacy” 28686E9C-0345-47E1-B5C6-FB030592A87D
July 20th, 2022
PLT Health Solutions, Inc announced the publication of a clinical study on its Boswellia serrata-based AprèsFlex 5-Day Joint Support ingredient that provides further evidence of its ability to support joint health and function with statistically significant improvements in pain scores and biomarkers starting at only 5 days from initial consumption.
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ApresFlex® Animal Health Product Sheet
March 24, 2022
Behind every ingredient solution is an even better story, download the product sheet to learn more.
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PLT Confirms Sustainability of Boswellia Serrata Supply through Third-Party Audit
February 23, 2022
Sustainability Expert Botanical Liaisons, LLC Conducts Audit of Harvesting and Collection Practices
Industry NewsPress Releases
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Nutraceutical Business Review: “Third-party confirms sustainability of PLT Boswellia serrata” 28686E9C-0345-47E1-B5C6-FB030592A87D
February 25th, 2022
Sustainability expert Botanical Liaisons has conducted an audit of the harvesting and collection practices of the substance commonly referred to as frankincense
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Mobility For a Life Better Lived
March 30, 2022

Healthy Aging for Every Age is The New Normal

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