AprèsFlex® for Animal Health
for a longer, happier life
Freedom to move.
It’s so important to the quality of their lives. AprèsFlex 5-Day Joint Support is a proprietary, botanical ingredient that can help a companion animal improve mobility, rapidly and then over an extended period. AprèsFlex helps manage inflammation that comes from aging or intense physical activity, so it is a perfect fit for companion animals throughout all phases of their lives.
Around the world, people have turned to AprèsFlex more than a billion times as a drug-free approach to joint comfort and enhanced mobility. They trust the science, trust the quality, and trust the experience. Now you can bring this same trusted ingredient to your animal health formulations.
Enhanced Joint Comfort They Can Count On
AprèsFlex 5-Day Joint Support has been the subject of extensive pre-clinical and clinical studies to understand its mechanism of action and its efficacy in supporting joint comfort and mobility.
Researchers examined the efficacy of AprèsFlex in supporting joint comfort and flexibility in a newly published randomized, double-blind clinical trial.1
- Visual Analog Score (VAS)
- The Lequesne algofunctional index (LFI)
- The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
- Various serum biomarkers (MMP3, TNF, hsCRP, COMP, CPII, and C2C)
Measurements were done on Days 0, 5, and 30
The study showed that AprèsFlex:
- Provided significant reduction (p<0.05) in all the pain scores at as early as five days when compared to the placebo
- Provided significant reduction (p<0.001) in all the pain scores when compared to baseline on day 30
Previous studies with AprèsFlex showed a 56% reduction in pain scores at 30 days. A similar study with AprèsFlex showed a 69% reduction in pain scores at 90 days.
Beyond joint comfort and flexibility improvements, AprèsFlex has also been shown clinically to impact biological markers associated with joint health and inflammation, including TNF-alpha, C-Reactive Protein (CRP), and Interleukin-6 (IL-6). It was also shown to significantly inhibit matrix metalloproteinase (MMP-3), an enzyme that breaks down cartilage, collagen, and connective tissue.
Sourced from Sustainable Boswellia Serrata Gum Resin
The starting point for AprèsFlex – Boswellia serrata – is a tree that produces Indian frankincense resin. AprèsFlex is selectively enriched to contain 20% Acetyl-11-keto-β-boswellic acid (AKBA) while reducing less active constituents. The bioavailability of AKBA from AprèsFlex was found to be significantly higher in comparison with that of other commercially available Boswellia extracts.
Boswellia serrata trees are native to much of India and the Punjab region that extends into Pakistan. In partnership with ingredient innovator Laila Pharmaceuticals, PLT is committed to the safety and fair treatment of the people who harvest AprèsFlex. We want to support the long-term health and well-being of the culture and the natural environment upon which it relies. For more information on our activities in these areas, visit www.plthealth.com/sustainability.
Every batch of the AprèsFlex harvest is assigned a specific batch number and each batch of finished products is traceable to a specific region and set of trees. AprèsFlex is tested and must comply with predefined specifications for different parameters at various stages of product manufacturing – from raw materials to finished products. Quality is monitored by a multi-disciplinary organization with dedicated departments for taxonomy (botanical Identification), raw material analysis, chemical analysis, microbiology, and more.
*Studies available upon request