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AprèsFlex® for Animal Health

Better mobility for companion animals
for a longer, happier life
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5 Days
AprèsFlex has been shown in clinical trials to improve joint comfort in humans as few as 5 days.
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1 Billion
Millions of people around the world have reached for a dose of AprèsFlex to enhance mobility.
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10 Studies
The science behind AprèsFlex is solid. It is supported by 7 pre-clinical and 3 human clinical trials.

Freedom to move.

It’s so important to the quality of their lives. AprèsFlex 5-Day Joint Support is a proprietary, botanical ingredient that can help a companion animal improve mobility, rapidly and then over an extended period. AprèsFlex helps manage inflammation that comes from aging or intense physical activity, so it is a perfect fit for companion animals throughout all phases of their lives.

Around the world, people have turned to AprèsFlex more than a billion times as a drug-free approach to joint comfort and enhanced mobility. They trust the science, trust the quality, and trust the experience. Now you can bring this same trusted ingredient to your animal health formulations.

Key Features

Human clinical trials have demonstrated that —–
  • 100 mg daily dose
  • Improved joint comfort in just 5 days*
  • 56% reduction in pain scores from baseline at 30 days*
  • 69% reduction in pain scores from baseline at 90 days*
  • 10 pre-clinical and clinical studies
  • Demonstrates significant 5-Lipoxygenase inhibition
  • Sustainable, botanical ingredient
Puppy and kitten and guinea pig
Good For
Ingredient Solutions
Animal Health & Well Being
Bone, Joint & Muscle
Healthy Aging
Soft Gels


Clinical Science
Clinical Science
NASC Member
NASC Member

Enhanced Joint Comfort They Can Count On

AprèsFlex 5-Day Joint Support has been the subject of extensive pre-clinical and clinical studies to understand its mechanism of action and its efficacy in supporting joint comfort and mobility.

Researchers examined the efficacy of AprèsFlex in supporting joint comfort and flexibility in a newly published randomized, double-blind clinical trial.1

Measurements included:

  • Visual Analog Score (VAS)
  • The Lequesne algofunctional index (LFI)
  • The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
  • Various serum biomarkers (MMP3, TNF, hsCRP, COMP, CPII, and C2C)

Measurements were done on Days 0, 5, and 30

The study showed that AprèsFlex:

  • Provided significant reduction (p<0.05) in all the pain scores at as early as five days when compared to the placebo
  • Provided significant reduction (p<0.001) in all the pain scores when compared to baseline on day 30

Previous studies with AprèsFlex showed a 56% reduction in pain scores at 30 days. A similar study with AprèsFlex showed a 69% reduction in pain scores at 90 days.

Beyond joint comfort and flexibility improvements, AprèsFlex has also been shown clinically to impact biological markers associated with joint health and inflammation, including TNF-alpha, C-Reactive Protein (CRP), and Interleukin-6 (IL-6). It was also shown to significantly inhibit matrix metalloproteinase (MMP-3), an enzyme that breaks down cartilage, collagen, and connective tissue.


Sourced from Sustainable Boswellia Serrata Gum Resin

The starting point for AprèsFlex – Boswellia serrata – is a tree that produces Indian frankincense resin. AprèsFlex is selectively enriched to contain 20% Acetyl-11-keto-β-boswellic acid (AKBA) while reducing less active constituents. The bioavailability of AKBA from AprèsFlex was found to be significantly higher in comparison with that of other commercially available Boswellia extracts.

Boswellia serrata trees are native to much of India and the Punjab region that extends into Pakistan. In partnership with ingredient innovator Laila Pharmaceuticals, PLT is committed to the safety and fair treatment of the people who harvest AprèsFlex. We want to support the long-term health and well-being of the culture and the natural environment upon which it relies. For more information on our activities in these areas, visit


Every batch of the AprèsFlex harvest is assigned a specific batch number and each batch of finished products is traceable to a specific region and set of trees. AprèsFlex is tested and must comply with predefined specifications for different parameters at various stages of product manufacturing – from raw materials to finished products. Quality is monitored by a multi-disciplinary organization with dedicated departments for taxonomy (botanical Identification), raw material analysis, chemical analysis, microbiology, and more.


*Studies available upon request

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