Identity & Quality You Can Trust
AquaLOX is a water-soluble version of PLT’s Boswellia Serrata extract 5-LOXIN®. 5-LOXIN has been clinically demonstrated to improve joint comfort and protect against cartilage degradation. In addition to being water-soluble, AquaLOX represents a major breakthrough with its pleasant taste profile, allowing – for the first time – the opportunity to feature PLT’s leading joint health solutions in taste-sensitive formulations such as chewables, gummies, stick-packs, shots and more.
Research that builds trust with consumers.
AquaLOX precursor, 5-LOXIN is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase enzyme. It has been the subject of 13 pre-clinical studies and 2 human clinical trials. One of the key features of 5-LOXIN in any formulation is the clinical work that has demonstrated efficacy starting at 7 days – at a significantly lower dose (100 mg) than other joint health ingredients. This fast efficacy and low dose allow 5-LOXIN to compete with non-natural or over-the-counter solutions.
Beyond joint comfort and flexibility improvements, 5-LOXIN also positively impacts biological markers associated with joint health and inflammation, including TNFa, CRP, and IL-6. It was also shown to significantly inhibit matrix metalloproteinase (MMP-3), an enzyme that breaks down cartilage, collagen and connective tissues.
Sustainability is a Key Value
The starting point for AprèsFlex – Boswellia serrata – is a plant that produces Indian frankincense. It is also known as Indian oli-banum, Salai guggul, and Sallaki in Sanskrit. The plant is native to much of India and the Punjab region that extends into Pakistan. In partnership with Laila, PLT is committed to the safety and fair treatment of the people who harvest AprèsFlex. We want to support the long-term health and well-being of the tribal culture and the natural environment upon which it relies.
Every batch of the AquaLOX harvest is assigned a specific batch number and each batch of finished product is traceable to a specific region and set of trees. AquaLOX x is tested and must comply with predefined specifications for different parameters at different stages of product manufacturing – from raw materials to finished product. Quality is monitored by a multi-disciplinary organization with dedicated departments for taxonomy (botanical Identification), raw material analysis, chemical analysis, microbiology and more
Pharmacokinetic Study Shows AquaLOX Matches 5-LOXIN
In a RDBC crossover clinical trial, healthy adults took either 40 mg AquaLOX (31.2 mg AKBA) or 100 mg 5-LOXIN (30 mg AKBA) in a random order on separate occasions. The results for AUC0-∞ (Area under the curve) showed that similar amounts of total AKBA were absorbed with each product. This demonstrated that the new product form was a highly efficient way of delivering the primary active ingredient.