Kinexa™ Joint Longevity Complex

Joint structure is the key to a lifetime of mobility

5

Key joint structures affected

24%

Improvement in knee strength*

10%

Improvement in cartilage thickness*

>49%

Improvement in joint comfort, function, and stiffness*

	Shown to preserve and improve 5 key joint structures: Cartilage, Menisci, Ligaments, Synovium, and Subchondral bone*
	Kinexa has also been down to improve knee strength and functional performance*
	24% improvement in knee strength*
	10% improvement in cartilage thickness*
	4% improvement in cartilage composition*
	Greater than 26% improvement in functional mobility*
	Greater than 49% improvement in joint comfort, function and stiffness*

CERTIFICATIONS

VEGAN

GLUTEN-FREE

NON-GMO

SOLVENT-FREE

Haritaki (Terminalia chebula)

A revered Ayurvedic herb known as the "King of Medicines"

Kinexa Ingredients

Tumeric (Curcuma longa)

A member of the ginger family, primarily known a a key ingredient in curry powder.

Indian Frankincense (Bowsellia serrata)

A potent Ayurvedic resin for thousands of years to reduce chronic inflammation

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

rhodiolife-rhodiola-1

Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

turmeric-curry-moringa-oleifera-ingredient-slendacor

Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

When it comes to understanding joint structure, imaging is everything

In the new clinical study, 100 subjects aged 40–75 with Grade II or III osteoarthritis received 200 mg/day of Kinexa or a matching placebo for six months. Assessments occurred at baseline, 1, 2, 4, and 6 months. Key subjective outcomes included WOMAC, VAS, and Lequesne Functional Index (LFI) scores. Functional measures included isometric knee torque, a 6-minute walk test, and a Timed Get Up and Go test. Advanced imaging assessed cartilage volume and thickness (MRI), cartilage composition (dGEMRIC MRI), and Whole Organ Magnetic Resonance Imaging Score (WORMS), a semi-quantitative MRI scoring of whole-joint structural integrity, which includes subchondral bone. Biomarkers of inflammation and cartilage metabolism were also evaluated.

Kinexa improved knee strength by 24%*

Kinexa Charts_Knee Strength

Kinexa significantly improved average Knee Extensor Torque across the 3 angles assessed (30°, 60°, 90°) vs. baseline and placebo at Days 30, 60, 120 and 180.

*Knee joint torque improved 24% relative to baseline in the Kinexa cohort over the 6-month study.

Kinexa improved cartilage thickness by 10%*

Kinexa Charts_Cartilage Thickness

Cartilage thickness, assessed by MRI, was significantly improved vs baseline and vs placebo in the Kinexa group, while in the placebo group, cartilage thickness significantly declined over the 6-month study.

*Cartilage thickness improved 10% relative to baseline in the Kinexa.

Kinexa significantly improved cartilage volume

Kinexa Charts_Cartilage Volume

Cartilage volume, assessed by MRI, significantly improved vs baseline in the Kinexa group, while in the placebo group, cartilage volume significantly declined versus baseline over the 6-month study.

Kinexa improved cartilage glycosaminoglycan concentration by 4%*

Kinexa Charts_Cartilage Composition

Cartilage composition, evaluated as glycosaminoglycan concentration via dGEMRIC-enhanced MRI, was significantly improved vs baseline and vs placebo in the Kinexa group. In the placebo group, the concentration of glycosaminoglycans in cartilage significantly declined over the 6-month study.

*Glycosaminoglycan concentration of cartilage improved 4% relative to baseline in the Kinexa group.

Kinexa significantly improved the health of the foundational bone in the joint

Kinexa Charts_Subchondral Bone Health

Subchondral Bone WORMS Composite Scores improved significantly versus baseline and placebo for the Kinexa group, while the placebo declined significantly over the 6-month study.

WORMS Subchondral Bone Composite Score is comprised of bone lesion, cysts, osteophyte and attrition scores.

Kinexa improved physical performance by 33%*

Kinexa Charts_Walking Speed

Kinexa significantly improved average walking speed in the Six-Minute Walk Test versus baseline and placebo at Days 30, 60, 120, and 180.

*Walking Speed improved 33% relative to baseline in the Kinexa group over the 6-month study.

Kinexa significantly improved the health of ligaments and menisci

Kinexa Charts_Ligaments & Menisci Health

Ligament & Menisci WORMS Composite Score improved significantly versus baseline and placebo for the Kinexa group, while the placebo scores declined significantly over the 6-month study.

WORMS Ligament & Menisci Composite Score is comprised of anterior/posterior cruciate and medial/lateral collateral ligaments.

Kinexa improved overall joint comfort, stiffness and function by 56%*

Kinexa Charts_Joint Pain, Stiffness & Function

Kinexa significantly improved Total WOMAC versus baseline and placebo at Days 30, 60, 120, and 180.
All WOMAC Subsets (Pain, Stiffness and Function) were also significantly improved with Kinexa versus baseline and placebo at Days 30, 60, 120 and 180.

*Total WOMAC improved 56% relative to baseline in the Kinexa group over the 6-month study.

Kinexa significantly improved synovial health

Kinexa Charts_Synovial Health

Synovial Health WORMS Composite Scores improved significantly versus baseline and placebo for the Kinexa group, while the placebo scores declined significantly over the 6-month study.

WORMS Synovial Health Composite Score includes synovitis, effusion, periarticular cysts and loose bodies.

Clinical Study: Kinexa and 5 Key Joint Structures

Over a six-month study, Kinexa was shown to preserve and improve five key joint structures: Cartilage, Menisci, Ligaments, Synovium, and Subchondral bone*

GET THE RESULTS

ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

Bone, Joint & Muscle Health

Kinexa opens up a new segment of the joint health category: whole joint health. It goes beyond managing symptoms toward a new understanding of bone and joint health, addressing a much broader range of factors that contribute to joint health and mobility.

Healthy Aging

When cartilage, meniscus, ligaments, and the foundation beneath the cartilage stay strong and resilient, the joint can absorb shock, distribute load evenly and remain stable through everyday life, training, aging, and wear-and-tear.

Active/Sports Nutrition

Kinexa addresses new realms of mobility improvement starting with comfort and flexibility and adding the potential for long-term protection.

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Behind the imaging technology used to validate Kinexa

To date, most clinical work in the joint health sector has focused on enhancing comfort. But joints aren’t just “pain sensors”. They are load-bearing mechanical systems. The new study on Kinexa is revolutionary because it makes use of imaging technology to demonstrate whole joint support.

MRI cartilage morphology evaluates the structure, thickness, and surface integrity of joint cartilage using magnetic resonance imaging (MRI). It assesses features such as cartilage thickness, volume, defects, and surface damage. Morphologic MRI helps detect cartilage degeneration, loss, or repair.

WORMS (Whole-Organ Magnetic Resonance Imaging Score) is a semiquantitative MRI scoring system used to evaluate the entire knee joint. It grades multiple structures—including cartilage, bone marrow lesions, menisci, ligaments, and synovium—across defined regions. WORMS provides an overall picture of joint health.

dGEMRIC (delayed Gadolinium-Enhanced MRI of Cartilage) is an MRI technique used to assess cartilage composition, particularly the concentration of glycosaminoglycans (GAGs), key molecules that maintain cartilage resilience and hydration. Lower dGEMRIC values indicate GAG loss and early cartilage degeneration, making the method useful for detecting biochemical cartilage changes before structural damage appears.

The Kinexa Stack

Kinexa is a new type of ingredient in the joint health space, supported by a clinical study that focuses on ‘whole joint structure. Most of today’s ingredients have science centered on comfort, stiffness, flexibility and function – based on subjective testing. Kinexa’s unique functionality and clinical work puts it in a position to be combined with these ingredients to create a new ‘stack’ for joint health.

A great example of this would be pairing 200 mg/day of Kinexa with PLT’s AprèsFlex 5-Day Joint Support. One of the leading joint health ingredients in the world, AprèsFlex is supported by four clinical studies that demonstrate joint comfort and other measures in just 5 days at a remarkably low 100 mg/day dose. This stack will offer consumers fast, experiential support plus objectively measured, imaging-validated structural benefits that support joint longevity.

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“Kinexa raises the bar because it evaluates the joint as a system, not just how it feels. This new study opens the door for our customers to develop new products that may contribute to long-term mobility across different life stages."

Jennifer Murphy, MS, RD, Head of Innovation & Clinical Science for PLT Health Solutions

Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

Kinexa™ Joint Longevity Complex

OVERVIEW

Kinexa is a clinically studied, whole-joint solution that preserves joint structure, builds functional strength and supports the entire joint as a system.

5

24%

10%

>49%

FEATURES & BENEFITS

Shown to preserve and improve 5 key joint structures: Cartilage, Menisci, Ligaments, Synovium, and Subchondral bone*

Kinexa has also been down to improve knee strength and functional performance*

24% improvement in knee strength*

10% improvement in cartilage thickness*

4% improvement in cartilage composition*

Greater than 26% improvement in functional mobility*

Greater than 49% improvement in joint comfort, function and stiffness*