MegaNatural-BP® Cardio Health Support
An ingredient that your customers will love – clinically studied support for health health
MegaNatural–BP is a patented, FDA no-objection GRAS ingredient shown to help support blood pressure levels that are already within normal range, and to help support normal arterial function. MegaNatural supports healthy blood pressure levels in subjects with pre-hypertension.
What makes MegaNatural Different?
California Natural Color’s MegaNatural grape seed extracts are traceable to the exact California vineyard they were grown in. Not all grape seed extract suppliers are able to make the same claim. Through relentless testing and painstaking record keeping, California Natural Color is able to guarantee that MegaNatural grape seed extracts remain adulterant free. Because ensuring the safety of consumers is of utmost importance, California Natural Color is a proud supporter of the American Botanical Council’s Botanical Adulterants Program.
Three clinical studies support
100% Water Soluble
Clean label extraction
High ORAC values
Efficacy shown for delivery via supplements and beverages
Three clinical studies support benefits from MegaNatural
Because multiple factors — from the grape varietals chosen, to the time of harvest, to the extraction technique — can influence the constituent profile of the finished product. The only way to know if a particular extract has biological efficacy is to test the specific composition of the extract.
Mechanism of Action
Edirisinghe I, Burton-Freeman B, Kappagoda CT Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin. Sci. 2008; 114: 331-337.
How does MegaNatural® BP work? Research using animal models indicates that it activates the enzyme nitric oxide synthase (eNOS) to produce nitric oxide (NO).
NO is a gaseous compound that acts as a cellular messenger. When NO is present in the inner lining of the blood vessels (endothelium), it causes the surrounding smooth muscle to relax. This endothelium-dependent relaxation of the blood vessels then supports healthy blood flow. *
MEGANATURAL ® –BP BEVERAGE REDUCED SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN PRE-HYPERTENSIVE SUBJECTS. AFTER WITHDRAWAL Of GRAPE SEED EXTRACT(GSE), BLOOD PRESSURE RETURNED TO PRE-STUDY LEVELS DEMONSTRATING EFFICACY OF THIS INGREDIENT.
Human Clinical Trial #1
Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58:1743-1746.
Study Type: randomized, double-blind, placebo-controlled
Methodology: Twenty-five subjects were randomized into three groups: a.) placebo, b.) 150 mg MegaNatural®-BP per day and c.) 300 mg MegaNatural®- BP per day. Each group took their respective treatment for four weeks.
Results: Blood samples showed MegaNatural®-BP to be well-absorbed after a single dose, with a steep rise in polyphenols 90 minutes after ingestion. After four weeks, both dosages of MegaNatural®-BP were found to help maintain blood pressure levels (both systolic and diastolic) within the normal range.* In addition, both dosages decreased levels of oxidized LDL cholesterol, with the 300 mg dosage reaching statistical significance compared to baseline. Low levels of oxidized LDL are correlated to arterial health. *
Human Clinical Trial #2
Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure subjects with pre-hypertension. J. Pharm. Nutri. Sci. 2012.
MegaNatural®-BP was found to help maintain blood pressure levels
Study Type: randomized, double-blind, placebo-controlled
Methodology: All 30 subjects began the trial by taking a placebo for two weeks. Then, they were randomized into two groups: a.) placebo and b.) 300 mg MegaNatural®-BP per day. Each group took their respective treatment for eight weeks.
Results: After eight weeks, MegaNatural®-BP was found to help maintain blood pressure levels (systolic and diastolic) within the normal range.*
Human Clinical Trial #3
Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomized, double-blinded, two-arm, parallel, placebo-controlled trial. Brit. J. Nutr. 2016; 115: 226-38.
Study Type: A single-center, randomized, double-blinded, placebo-controlled, 12-week, parallel study
Methodology: 29 middle-age adults with pre-hypertension consumed a fruit-flavored beverage placebo or 150 mg MegaNatural®-BP twice per day (300 mg per day) in a fruit-flavored beverage for six weeks, preceded by two-week placebo run-in and four-week no-beverage follow-up.
Results: After six weeks, MegaNatural®-BP was found to help maintain blood pressure levels within the normal range. * After four weeks of discontinuation of GSE beverage, blood pressure increased to original levels.
Delivering On the goodness of the grape(seed)
Grapes have been with us throughout human history. The cultivation of grapes is thought to have begun over 8.000 years ago in the Middle East – with the earliest recorded winery dating back to 4,000 BCE. Grapes contain a variety of phytochemicals, like phenolic acids, stilbenes, anthocyanins, and proanthocyanidins, all of which are strong antioxidants.
PLT innovation partner, California Natural Color, is a division of E. & J. Gallo Winery, the largest premium wine company in the world. This gives the company access to an abundant supply of fresh wine grapes, grown in California’s Central Valley, where it retains complete control over the entire manufacturing process — from the initial selection of wine grapes to final extraction of finished material
MegaNatural grape seed extracts are traceable to the exact California vineyard they were grown in. Not all grape seed extract suppliers are able to make the same claim. Through relentless testing and painstaking record keeping, PLT innovation partner California Natural Color can guarantee that MegaNatural grape seed extracts remain adulterant free. Because ensuring the safety of consumers is of utmost importance, California Natural Color is a proud supporter of the American Botanical Council’s Botanical Adulterants Program.
In addition to the natural benefit of our MegaNatural® grape seed extracts, it is also important to note that thee clinically studied grape seed extracts are produced using a patented hot water extraction process for maximum effectiveness. MegaNatural grape seed extracts have been granted a no-objection generally recognized as safe (GRAS) status by the Food and Drug Administration (FDA).
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