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MegaNatural-BP® Heart Health Formula

Clinically evaluated cardiovascular benefits
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100% water soluble
MegaNatural-BP can be used in a wide range of products and delivery systems.
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94.6% polyphenols
MegaNatural-BP has an industry-leading concentration of polyphenols with a high ORAC value.
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6 weeks
Clinical studies have shown that MegaNatural-BP after just 6 weeks!
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150 mg
Clinical studies showed efficacy of MegaNatural-BP at both 150 mg and 300 mg doses.

An ingredient that your customers will love

MegaNatural–BP is a patented, FDA no-objection GRAS ingredient shown to help support blood pressure levels that are already within normal range, and to help support normal arterial function. MegaNatural supports healthy blood pressure levels in subjects with pre-hypertension.

What makes MegaNatural Different?

Polyphenolics’ MegaNatural grape seed extracts are traceable to the exact California vineyard they were grown in. Not all grape seed extract suppliers are able to make the same claim. Through relentless testing and painstaking record keeping, Polyphenolics is able to guarantee that MegaNatural grape seed extracts remain adulterant free. Because ensuring the safety of consumers is of utmost importance, Polyphenolics is a proud supporter of the American Botanical Council’s Botanical Adulterants Program.

Key Features
    • Three clinical studies support the effectiveness of MegaNatural-BP in improving blood pressure
    • Efficacy shown for delivery via supplements and beverages
    • Patented
    • All natural
    • 100% Water Soluble
    • High pH stable
    • GRAS approved
    • Non-GMO
    • High ORAC Values
Good For
Ingredient Solutions
Antioxidant Support
Stick Packs
woman runner jogger taking pulse

The MegaNatural-BP Advantage

Heart Health

100% water-soluble MegaNatural-BP can be featured in a broad range of heart health support products via virtually any delivery system you can imagine.

Highly consistent

The consistency of every batch of MegaNatural-BP is verified through specialized HPLC testing, the accepted protocol for measuring polyphenol profiles. Consistent activity guarantees consistent results.

Structurally unique

By investing heavily in research that identifies and “captures” the molecular structures within grape seed shown to provide specific health benefits, Polyphenolics has developed a grape seed extract that is structurally unique, providing 90-95% total polyphenols — the biologically active constituents.

Improved bioavailability

Because MegaNatural-BP is selectively extracted to include a higher percentage of lower molecular weight polyphenols, it has improved bioavailability and greater absorption compared to other grape seed extracts.


Three clinical studies support benefits from MegaNatural

Because multiple factors — from the grape varietals chosen, to the time of harvest, to the extraction technique — can influence the constituent profile of the finished product. The only way to know if a particular extract has biological efficacy is to test the specific composition of the extract.

Mechanism of Action

Edirisinghe I, Burton-Freeman B, Kappagoda CT Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin. Sci. 2008; 114: 331-337.

How does MegaNatural® BP work? Research using animal models indicates that it activates the enzyme nitric oxide synthase (eNOS) to produce nitric oxide (NO).

NO is a gaseous compound that acts as a cellular messenger. When NO is present in the inner lining of the blood vessels (endothelium), it causes the surrounding smooth muscle to relax. This endothelium-dependent relaxation of the blood vessels then supports healthy blood flow. *


Human Clinical Trial #1

Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58:1743-1746.

Study Type: randomized, double-blind, placebo-controlled

Methodology: Twenty-five subjects were randomized into three groups: a.) placebo, b.) 150 mg MegaNatural®-BP per day and c.) 300 mg MegaNatural®- BP per day. Each group took their respective treatment for four weeks.

Results: Blood samples showed MegaNatural®-BP to be well-absorbed after a single dose, with a steep rise in polyphenols 90 minutes after ingestion. After four weeks, both dosages of MegaNatural®-BP were found to help maintain blood pressure levels (both systolic and diastolic) within the normal range.* In addition, both dosages decreased levels of oxidized LDL cholesterol, with the 300 mg dosage reaching statistical significance compared to baseline. Low levels of oxidized LDL are correlated to arterial health. *

Human Clinical Trial #2

Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure subjects with pre-hypertension. J. Pharm. Nutri. Sci. 2012.

MegaNatural®-BP was found to help maintain blood pressure levels

Study Type: randomized, double-blind, placebo-controlled

Methodology: All 30 subjects began the trial by taking a placebo for two weeks. Then, they were randomized into two groups: a.) placebo and b.) 300 mg MegaNatural®-BP per day. Each group took their respective treatment for eight weeks.

Results: After eight weeks, MegaNatural®-BP was found to help maintain blood pressure levels (systolic and diastolic) within the normal range.*

Human Clinical Trial #3

Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomized, double-blinded, two-arm, parallel, placebo-controlled trial. Brit. J. Nutr. 2016; 115: 226-38.

Study Type: A single-center, randomized, double-blinded, placebo-controlled, 12-week, parallel study

Methodology: 29 middle-age adults with pre-hypertension consumed a fruit-flavored beverage placebo or 150 mg MegaNatural®-BP twice per day (300 mg per day) in a fruit-flavored beverage for six weeks, preceded by two-week placebo run-in and four-week no-beverage follow-up.

Results: After six weeks, MegaNatural®-BP was found to help maintain blood pressure levels within the normal range. * After four weeks of discontinuation of GSE beverage, blood pressure increased to original levels.

Tap the Greatness of Grapes!

MegaNatural® GOLD Grape Seed Extract – guarantees a minimum 90% polyphenols and a standardized composition of monomers, oligomers and polymers.

MegaNatural® Red Grape SD Kosher Extract – is similar to bilberry extract in composition with a minimum of 15% anthocyanins and 45% total phenols. Therefore, it could be used in conjunction with bilberry in eye care products.

MegaNatural® GSKE-40 Grape Pomace Extract – made from grape skins, grape seeds and grape stems and is classified as a grape pomace extract and has a minimum of 80% total phenols.

MegaNatural® RW Grape Extract – produced from 100% California Rubired grapes



Polyphenolics is a business unit of California Natural Color, a division of E&J Gallo Winery

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