MegaNatural-BP® Heart Health Formula
An ingredient that your customers will love
MegaNatural–BP is a patented, FDA no-objection GRAS ingredient shown to help support blood pressure levels that are already within normal range, and to help support normal arterial function. MegaNatural supports healthy blood pressure levels in subjects with pre-hypertension.
What makes MegaNatural Different?
Polyphenolics’ MegaNatural® grape seed extracts are traceable to the exact California vineyard they were grown in. Not all grape seed extract suppliers are able to make the same claim. Through relentless testing and painstaking record keeping, Polyphenolics is able to guarantee that MegaNatural® grape seed extracts remain adulterant free. Because ensuring the safety of consumers is of utmost importance, Polyphenolics is a proud supporter of the American Botanical Council’s Botanical Adulterants Program.
Three clinical studies support the effectiveness of MegaNatural-BP in improving blood pressure
Efficacy shown for delivery via supplements and beverages
100% Water Soluble
High pH stable
High ORAC Values
Three clinical studies support benefits from MegaNatural
Because multiple factors — from the grape varietals chosen, to the time of harvest, to the extraction technique — can influence the constituent profile of the finished product. The only way to know if a particular extract has biological efficacy is to test the specific composition of the extract.
Mechanism of Action
Edirisinghe I, Burton-Freeman B, Kappagoda CT Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin. Sci. 2008; 114: 331-337.
How does MegaNatural® BP work? Research using animal models indicates that it activates the enzyme nitric oxide synthase (eNOS) to produce nitric oxide (NO).
NO is a gaseous compound that acts as a cellular messenger. When NO is present in the inner lining of the blood vessels (endothelium), it causes the surrounding smooth muscle to relax. This endothelium-dependent relaxation of the blood vessels then supports healthy blood flow. *
MEGANATURAL ® –BP BEVERAGE REDUCED SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN PRE-HYPERTENSIVE SUBJECTS. AFTER WITHDRAWAL Of GRAPE SEED EXTRACT(GSE), BLOOD PRESSURE RETURNED TO PRE-STUDY LEVELS DEMONSTRATING EFFICACY OF THIS INGREDIENT.
Human Clinical Trial #1
Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58:1743-1746.
Study Type: randomized, double-blind, placebo-controlled
Methodology: Twenty-five subjects were randomized into three groups: a.) placebo, b.) 150 mg MegaNatural®-BP per day and c.) 300 mg MegaNatural®- BP per day. Each group took their respective treatment for four weeks.
Results: Blood samples showed MegaNatural®-BP to be well-absorbed after a single dose, with a steep rise in polyphenols 90 minutes after ingestion. After four weeks, both dosages of MegaNatural®-BP were found to help maintain blood pressure levels (both systolic and diastolic) within the normal range.* In addition, both dosages decreased levels of oxidized LDL cholesterol, with the 300 mg dosage reaching statistical significance compared to baseline. Low levels of oxidized LDL are correlated to arterial health. *
Human Clinical Trial #2
Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure subjects with pre-hypertension. J. Pharm. Nutri. Sci. 2012.
MegaNatural®-BP was found to help maintain blood pressure levels
Study Type: randomized, double-blind, placebo-controlled
Methodology: All 30 subjects began the trial by taking a placebo for two weeks. Then, they were randomized into two groups: a.) placebo and b.) 300 mg MegaNatural®-BP per day. Each group took their respective treatment for eight weeks.
Results: After eight weeks, MegaNatural®-BP was found to help maintain blood pressure levels (systolic and diastolic) within the normal range.*
Human Clinical Trial #3
Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomized, double-blinded, two-arm, parallel, placebo-controlled trial. Brit. J. Nutr. 2016; 115: 226-38.
Study Type: A single-center, randomized, double-blinded, placebo-controlled, 12-week, parallel study
Methodology: 29 middle-age adults with pre-hypertension consumed a fruit-flavored beverage placebo or 150 mg MegaNatural®-BP twice per day (300 mg per day) in a fruit-flavored beverage for six weeks, preceded by two-week placebo run-in and four-week no-beverage follow-up.
Results: After six weeks, MegaNatural®-BP was found to help maintain blood pressure levels within the normal range. * After four weeks of discontinuation of GSE beverage, blood pressure increased to original levels.
Tap the Greatness of Grapes!
MegaNatural® GOLD Grape Seed Extract – guarantees a minimum 90% polyphenols and a standardized composition of monomers, oligomers and polymers.
MegaNatural® Rubired Grape Juice Extract – is similar to bilberry extract in composition with a minimum of 25% anthocyanins and 45% total phenols. Therefore, it could be used in conjunction with bilberry in eye care products.
MegaNatural® GSKE Grape Pomace Extract – made from grape skins, grape seeds and grape stems and is classified as a grape pomace extract and has a minimum of 80% total phenols.
GSKE-40 Grape Pomace Extract – made from grape skins, grape seeds, and stems and has a minimum of 40% total phenols.
Nutraceutical Grape Pomace Extract – made from grape skins, grape seeds, and stems and has a minimum of 25% total phenols.
MegaNatural® RED WINE Concentrate – produced from 100% California Rubired grapes
Ready to realize your product’s full potential?
We work closely with our customers and our world-wide suppliers to source and scientifically back innovative ingredients for your product development needs.