PROMUNEL® Ultra-Performance Propolis

The Gold Standard in Propolis

6 Polyphenols

PROMUNEL is standardized to 6 polyphenols with the most antimicrobial activity.

26% Lower Incidence

PROMUNEL reduced the number of subjects experiencing Upper Respiratory Tract Infections

31% Lower

PROMUNEL lowered the incidence of URTI symptoms

34% Fewer Days

PROMUNEL reduced the length of time test subjects experienced symptoms

	Demonstrated efficacy from 2 double-blind, placebo controlled clinical trials
	Unique multi-dynamic extraction process
	Extracts are devoid of undesirable compounds
	Extracts are standardized to 6 markers
	Liquid, powder & formulated forms
	Dispersible in water
	Supports bee-keeping industry

PROMUNEL Hex Illustration with callouts_transparent background

CERTIFICATIONS

VEGAN

GLUTEN-FREE

SOLVENT-FREE

NON-GMO

HALAL

KOSHER

A Traditional Ingredient…Standardized

PROMUNEL is based on propolis from beekeeping. Processing involves purification, removal of waxes and resins, extraction, and concentration. It is standardized on six bioactive polyphenols in propolis: chrysin, galangin, pinocembrin, apigenin, pinobanksin, and quercetin.

A Gift from Honeybees

Propolis is a resinous substance that honeybees produce by mixing saliva, beeswax, and exudate gathered from trees and other botanical sources.

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Maintains Microbiological Health

Propolis is used as a sealant for open spaces in the hive and helps maintain microbiological health of bees.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

PROMUNEL is Clinically Studied

Clinical Trial #1

PROMUNEL has been the subject of two double blind placebo controlled clinical trials. In both studies, subjects taking PROMUNEL showed a lower incidence of Upper Respiratory Tract Infections (URTI), less sever symptoms and a shorter duration of symptoms.

DESIGN

R-DBPC trial, N = 122 healthy adults with mild URTI

8 weeks of follow-up

INTERVENTION

PROMUNEL oral spray (15 mg/ml polyphenols) vs placebo

Dose: 2-4 sprays (12-24 mg of polyphenols), 3x a day TID for five days

RESULTS

After 3 days of treatment, 83% of subjects treated with PROMUNEL had remission of 43 symptoms, while 72% of subjects in the placebo group had at least one remaining symptom.

Healing from uncomplicated URTIs took place two days earlier, instead of taking place in five days as recorded in the control group.

Clinical Trial #2

DESIGN

R-DBPC trial, N = 295 healthy adults (159 women/136 men)

12 weeks (Autumn to Spring Period)

INTERVENTION

PROMUNEL capsules (400mg/day)

RESULTS

PROMUNEL supplementation reduced the number of subjects experiencing upper respiratory discomforts by 26%. It also reduced the risk of experiencing discomfort by 31% and the number of days of symptoms by 34%.

PROMUNEL reduces the incidence of upper respiratory discomfort events.

Clinical Study: Support for Cold Symptoms

After 3 days of treatment, 83% of subjects treated with PROMUNEL had remission of 43 cold symptoms, while 72% of subjects in the placebo group had at least one remaining symptom.

GET THE RESULTS

Clinical Study: Lowering the Risk of URTIs

A 12 Week study on 295 healthy subjects showed that PROMUNEL helped reduce the incidence of URTIs, ease symptoms and shorten symptom duration.

GET THE RESULTS

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ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

Immune Health

PROMUNEL offers a novel approach to immune health – along with clinical science and a compelling origin story.

Respiratory Health

The PROMUNEL clinical study suggests it as a complementary ingredient in respiratory health formulations.

APPLICATIONS

BEVERAGES

CAPSULES

CHEWS

GUMMIES

EFFERVESCENTS

POWDERS

RTDS/SHOTS

SOFT GELS

STICK PACKS

TABLETS

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ORIGIN STORY

Using Products from Bees to Heal and Survive

Bee products, especially honey and propolis, have found widespread use for centuries in traditional medicine. Egyptians used propolis to stop the decomposition of bodies during the mummification process. Greeks were the first to transform beekeeping into farming.

Recognized for Centuries

Pliny the Elder, in his Natural History, coined the name propolis: PRO=before + POLIS=town. Egyptians used propolis to stop the decomposition of bodies during the mummification process. Hippocrates prescribed propolis for various kinds of disorders, both internal and external. The amazing properties of bee products were recognized for centuries in Arab cultures, and they are even mentioned in several verses of the Koran.

Beekeeping: A Contract With The Honeybees

With PROMUNEL, bees are a part of the team. In a world where wild bees are disappearing at alarming rates, it seems as if beekeeping may be their only hope of survival.

A Win-Win Situation

The producers of PROMUNEL engage their beekeeper suppliers to defend and protect their colonies – never over sourcing and providing healthy environments, free of pesticides and other contaminants. We call it a ‘contract’ with the bees and hope for a win-win situation.

Patented Processing Creates Standardized Starting Material

M.E.D.® stands for Dynamic Multi Extraction. M.E.D.® is a technology of extraction developed and patented by B Natural, to obtain the most active principles and ensure products are highly purified with no uninteresting substances and no contaminants.

The standard method of extraction of Polyphenols from Propolis involves the use of a single solvent. The result is a partial extraction. The M.E.D.® uses various concentrations of solvent during the whole production process, extracting polyphenols with different solubility and especially flavonoids, phenolic acids, and glycosylated fractions. This yields the “Mother Extract” from which all grades of PROMUNEL are produced. This ensures that all grades of PROMUNEL have the same fingerprint of the six primary marker polyphenols.

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PROMUNEL is standardized to six marker polyphenols, preserving and optimizing the synergistic effect of the most important active constituents found in native propolis. With PROMUNEL, unlike commodity propolis, the dose is consistent, and health benefits are reproducible. No other propolis even comes close to this level of identification, consistency, and standardization of bioactives.

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How PROMUNEL Stands Out From Most Propolis

Both the season and region in which propolis is collected influence its chemical composition, resulting in variations in biological activity. Significant differences in composition and concentration of certain chemical compounds in propolis make standardization and quality control challenging. In addition, the lack of uniformity in evaluation methodology and analytical techniques, make it extremely difficult to correlate data across the climatic zones.

To make a standardization and quality control of this product is very difficult, particularly if we take into account the quantification of the active substances.

Adulteration of propolis with poplar extract is a serious issue in the bee products market.”

The genuine article is not easy to identify. Propolis can be more or less any color from green to red… Bees have even been known to make fraudulent propolis themselves, sometimes exploiting window putty in place of plant buds.

1. J Apicultural Res. 2019;58(4): 604–16.
2. J Pharm Bioallied Sci. 2011 Oct-Dec; 3(4): 479–95.
3. Molecules. 2014;19(7):10208-10217.
4. Chemistry World. 2007 Aug 28.

Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

PROMUNEL® Ultra-Performance Propolis

OVERVIEW

PROMUNEL® offers advantages over conventional propolis ingredients, delivering high quality and consistency of raw materials and a unique, patented extraction process.

6 Polyphenols

26% Lower Incidence

31% Lower

34% Fewer Days

FEATURES & BENEFITS

Demonstrated efficacy from 2 double-blind, placebo controlled clinical trials

Unique multi-dynamic extraction process

Extracts are devoid of undesirable compounds

Extracts are standardized to 6 markers

Liquid, powder & formulated forms

Dispersible in water

Supports bee-keeping industry

CERTIFICATIONS

A Traditional Ingredient…Standardized

A Gift from Honeybees

Maintains Microbiological Health

Rhodiola rosea

Exciting Phytochemistry

Detail 1

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RESEARCH

PROMUNEL is Clinically Studied

Clinical Trial #1

DESIGN

INTERVENTION

RESULTS

Clinical Trial #2

DESIGN

INTERVENTION

RESULTS

PROMUNEL helps lower the risk of experiencing upper respiratory discomforts.

PROMUNEL helps shorten the number of days of upper respiratory discomforts.

CLINICAL HIGHLIGHTS

Clinical Study: Support for Cold Symptoms

Clinical Study: Lowering the Risk of URTIs

MARKET OPPORTUNITIES

Immune Health

Respiratory Health

APPLICATIONS

ORIGIN STORY

Using Products from Bees to Heal and Survive

Recognized for Centuries

Beekeeping: A Contract With The Honeybees

A Win-Win Situation

QUALITY

Patented Processing Creates Standardized Starting Material

INSIGHTS

How PROMUNEL Stands Out From Most Propolis

“PROMUNEL is a way that consumer products companies can differentiate their immune health products”

RESOURCES

Ready for something different in your immune health products?