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Delivering an alert serenity that impacts mood, focus, and an overall sense of well-being.
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25 mg
Clinical studies have shown that Zembrin delivers its benefits at a very low dose.
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2 hours
Zembrin is experiential. Studies have shown that it starts delivering in as little as 2 hours from use.
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1 billion
Number of times Zembrin has been reached for around the world to provide experiential stress relief.
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Zembrin was awarded the first ever Export and Bioprospecting permit to be issued by the South African government - #001. in recognition of its environmentally sustainable production and socially responsible indigenous benefit-sharing agreement.

Help Them Live their Best Lives

Stress takes a toll on everyone it touches – contributing to health problems, poor relationships and lost productivity at work. It can also affect our ability to perform at our best.

Zembrin can help give people power over their lives by introducing a sense of calm serenity or alert focus. Clinically-studied, it has been shown to start working in as little as 2 hours and is safe enough to be used every day for months.

Zembrin is not an anti-depressant, but it helps with calmness and serenity. It’s not a stimulant, but it helps with alertness and focus. It doesn’t cause drowsiness. It has no harmful side effects and does not present addiction potential – unlike many pharmaceuticals that may offer the same benefits.

PLT and HG&H's Partnership at Work

PLT works with some of the most innovative, socially-committed companies in the world in bringing our solutions for health & wellness to market. HG&H Pharmaceuticals from South Africa is a unique company with a fascinating story to tell your customers.

Good For
Ingredient Solutions
Active Nutrition
Cognitive and Mood Support
Weight Management
Stick Packs
RTDs / Shots

Active/Sports Nutrition

Motivation is considered by many to be the single most important element of any training program. If you’re not out there, you’re not improving. At the same time, loving every minute of training, every day can be a challenge. Training requires focus and overcoming the stresses of everyday life. That’s where adding Zembrin to your sports formulation can help.

Cognitive & Mood

Zembrin has been clinically demonstrated to improve cognitive function – specifically cognitive flexibility and executive function. Additionally, tests have shown reduction of stress and improvement of mood, manifested through statistically significant improved quality of sleep, less fatigue, enhanced work performance, enhanced interest in daily activities and lower levels of irritability, worry and insecurity. One of the most intriguing aspects of Zembrin is that it is experiential – users “feel” its benefits.

Weight Management

Experts are increasingly recognizing the role of cognitive support in long-term weight management programs. Zembrin can help make the long road to weight loss success seem just a little less long.


One of the industry’s most advanced science programs

Zembrin has been the subject of one of the most extensive and forward-thinking clinical science programs in the nutraceutical industry.

One study of Zembrin featured functional Magnetic Resonance Imaging (fMRI) technology to examine the effects of acute supplementation on the “threat circuitry” of the human brain. That study showed that 25 mg of Zembrin reduced anxiety-related activity of the amygdala and its associated anxiety circuitry within 2 hours of administration.

Another study featured the use of quantitative electroencephalogram (EEG) monitoring of subjects using Zembrin. The study showed efficacy of Zembrin seen from three levels of evidence: psychometric tests (CPT and NCT), questionnaire (HAMA), and on the electrical activity of the brain.

Zembrin’s clinical program has traveled the journey from mechanistic understanding of Zembrin’s function to relevant clinical endpoints in humans, supporting consumer communications about improved well-being. The present indications for Zembrin, as a dietary supplement are to elevate mood, relieve stress and improve cognition (focus). Adjectives like “anti-stress, calmness, focused, serenity, motivated, energy, improves sleep” are often used to describe the experiential effects of Zembrin.

How does Zembrin work?

In the body, Zembrin functions as both a serotonin reuptake inhibitor and a phosphodiesterase 4 inhibitor. SRIs are used predominantly as antidepressants and are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders. Zembrin’s unique dual mode of action is patented, and it is the dual inhibition of 5-HT uptake and PDE4 is rapid onset of action and the synergistic activity allowing low doses to be used with excellent tolerability.

Zembrin is Experiential

One of the most intriguing aspects of Zembrin is that it is experiential – users “feel” its benefits. It is also fast acting. A published study that used functional Magnetic Resonance Imaging (fMRI) technology to examine the effects of short term supplementation with Zembrin on the “threat circuitry” of the human brain showed statistically-significant reductions in anxiety-related activity of the amygdala and its associated anxiety circuitry within 2 hours of administration.

Cognitive Support for Peak Performance

At PLT Health Solutions, we have been focusing on what we consider to be an underserved demographic – the 18-54 age range. Within this group, we see intense interest in issues such as ‘peak performance’, ‘well-being’ and ‘quality of life’. The market opportunity with this group is massive. Peak performers including knowledge workers and students make up 40% of the US population and is growing. Stress affects 75 million people in this group. And the impact of cognitive performance on other aspects of life is becoming better understood by this demographic– as evidenced by the introduction of ingredients to improve mental performance in exercise via sports nutrition products as well as easier weight management.

Cognitive Support for Sports & Weight Management

Increasingly, PLT is seeing the adoption of Zembrin as part of multi-ingredient formulations where cognitive support is desired to help achieve specific goals. The sports nutrition community has discovered Zembrin and is using it in workout products with the goal of providing cognitive support leading to enhanced focus and better workouts. Recently, there has been a good deal of discussion of the potential role of cognitive support in the weight management sector. The concept is two-fold. The first area has to do with the notion that weight loss can be a stressful time and that cognitive support can help maintain compliance with a weight management program. The second has to do with providing daily, experiential support. Successful weight management involves diet, exercise and slow, consistent weight loss. Weight management ingredients are studied over periods of 16 weeks and longer. The idea is that the use of an experiential ingredient like Zembrin can give immediate positive reinforcement and enhanced mood every day over this process.

Zembrin is Ethically-Sourced

As part of its development program, Zembrin was awarded the first ever Export and Bioprospecting permit to be issued by the South African government, #001, which was issued compliant with the National Environmental Management; Biodiversity Act, Act 10 of 2004 (NEMBA) and its associated Bioprospecting, Access and Benefit Sharing or BABS Regulations of 2008.

Zembrin is the impetus for Africa’s first prior-informed consent benefit-sharing agreement, signed with the South African San Council after 2 years of negotiation, to formally recognize the primary indigenous knowledge holders of Sceletium. The beneficiaries of the bioprospecting project include the South African San Council (San).

Related Offsite Articles
Health Canada approves Zembrin cognitive claim
The Sport Journal
How Mindfulness Training may mediate Stress, Performance and Burnout

Deliver stress relief your customers can feel.

PLT has a broad range of cognitive health support solutions with strong scientific support. Find out how we can help you put these ingredients to work in your products.