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    Seth Flowerman
    President and CEO

Rhodiolife® Rhodiola rosea

Reaching new heights in Rhodiola quality and sustainability
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OVERVIEW

Rhodiolife generates sustained energy and promotes wellness including psychological, emotional and physical conditioning.

3 Published Studies

3 Published Studies

Rhodiolife is backed by science that supports its benefits.

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Fingerprint Matters

Only Rhodiolife’s unique “fingerprint” composition consistently provides the spectrum of compounds found in the root of the plant.

CITES Compliant

CITES Compliant

CITES compliant Rhodiolife is now sourced from both wildcrafted and cultivated raw materials.

3rd PARTY VERIFIED

3rd Party Verified

Rhodiolife is the world’s first Rhodiola rosea third-party verified for ingredient identity and sustainable sourcing.

FEATURES & BENEFITS

 

Consistent, standardized extracts

Cultivation program in place

Sustainable, socially responsible

Full ID assessment and traceability

Sourced from Altai Mountains

Secure supply

3 published clinical studies

Self-affirmed GRAS

Water-soluble

Non-GMO Project Verified

 

 

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CERTIFICATIONS

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CLINICAL SCIENCE

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KOSHER

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HALAL

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NON-GMO

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GRAS

BSCG CERTIFIED FOR SPORTS

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3RD PARTY VERIFIED SUSTAINABLE

A True Adaptogen. Standardized. Sustainable.

Rhodiolife is a standardized extract of Rhodiola rosea – which is considered a true adaptogen. Only Rhodiolife’s unique “fingerprint” composition consistently provides the spectrum of compounds found in the root of the plant that are responsible for its biological activity .

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

 

RESEARCH


Complementing the body of published work on Rhodiola rosea, preclinical and clinical trials using Rhodiolife have been conducted and publishe

Rhodiolife increases physical working capacity - pre-clinical

Design
• 24 Sprague-Dawley Rats given R. rosea (Rhodiolife), R. crenulata, or control via oral gavage (50 mg/kg)
• Twice-daily exhaustive swimming sessions for six days
• Outcomes measured
• Time to exhaustion
• Skeletal muscle mitochondrial ATP


Results
• Mean time to exhaustion was virtually the same in rats treated with R. crenulata and controls (34.2-35.5 minutes)
• Mean time to exhaustion in Rhodiolife-treated rats was far greater (45 minutes)
• ATP content in the mitochondria decreased after swimming exercise in all animals.  However, the decrease in rats receiving Rhodiolife was less pronounced  in comparison with not only the control, but also with the R. crenulata group (p<0.05)

In this animal study, the effects of two different Rhodiola extracts were studied on physical performance and muscle health.

The graph shows that rats supplemented with RhodioLife were able to swim almost 25% longer than control or R. crenulata supplemented rats.  This may be due in part to the ability of R. rosea extract to activate the synthesis or resynthesis of ATP in mitochondria and stimulate reparative energy processes during and after intense exercise.  As shown in Table 1, rats in the RhodioLife supplemented group had less of a decline in muscle ATP than did rats in either of the other 2 groups.

NOTE: Salidroside content in R. crenulata extract was 2.5 times higher than in R. rosea extract. Hence, the effects of R. rosea extract are due to the presence of rosavins and/or their complex with other compounds.

REF: Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of Extracts from Rhodiola Rosea and Rhodiola Crenulata (Crassulaceae) Roots on ATP Content in Mitochondria of Skeletal Muscles. Bull Expo Biol Med. 2003;136(6):585–7.

Rhodiolife produces brain-wave activity similar to ginkgo

Quantitative EEG Discriminant Analysis provides a unique comparison

Design
• Male adult Fischer rats implanted with qEEG electrodes
• Rhodiolife extract administered orally by gavage (100 mg/kg)
• Outcomes measured
     • Analysis of spectral power by qEEG 
     • In vitro hippocampal slice analysis


Results

• Rhodiola attenuated delta and theta power, likely related to interference with the cholinergic and norepinephrinergic transmission, respectively.
• Using discriminant analysis for comparison with reference pharmaceutical and botanical drugs, Rhodiola projected near the position of Ginkgo extract.

Dimpfel W, Schombert L, Vega-Morales T, Wiebe JC.  Neuropharmacological Characterization of Extracts from Rhodiola rosea, Oenothera paradoxa and Paullinia cupana in Comparison to Caffeine. Pharmacol Pharm. 2016;7(7). DOI: 10.4236/pp.2016.77036

Rhodiolife supports muscle during exercise

Anti-inflammatory and muscle-protective effects in humans

RhodioLife has also been studied in untrained humans as well.  In this study, subjects consumed RhodioLife before and after exhausting physical exercise on an ergometer.  

Design
• N=36 healthy, untrained volunteers aged 21-24 years
• Supplemented 30 d prior and 6 d after exhausting physical exercise with:
     • Placebo (340 mg twice/day)
     • Rhodiola rosea (Rhodiolife, 340 mg twice/day)
     • Control (no treatment)

Results
• Less pronounced rise in CRP in the Rhodiolife group. Levels returned to baseline only in this group.
• Creatine Kinase (CK) was also blunted in the Rhodiolife supplemented subjects

Rhodiolife may reduce occasional anxiety

Pilot clinical trial in adults with anxiety

In this small, pilot study, 10 participants with DSM-IV diagnosis of generalized anxiety disorder were supplemented with RhodioLife for 10 weeks.  Several assessments to clinically evaluate symptoms at baseline and following supplementation were used.

Design
• N=10 subjects with anxiety
• Open-label design
• Rhodiola rosea (Rhodiolife) 340 mg/d for 10 weeks
• Assessments:
     • Hamilton Anxiety Rating Scale (HAM-A or HARS) and Hamilton Depression Rating Scale (HAM-D or HDRS)
     • Four-Dimensional Anxiety and Depression Scale (FDADS)
     • Clinical Global Impressions of Severity/Improvement Scale

Results
• Daily Rhodiolife consumption decreased ratings on scales of anxiety (HAM-A) and depression (HAM-D). (p=0.001)
• Self-rated scores on FDADS also significantly decreased (p=0.043

*p<0.05 vs control, placebo

Abidov M et al. Bull Exp Biol Med 2004;7:63-4.

A less pronounced rise in the inflammatory marker C-reactive protein was observed in the Rhodiolife supplemented subjects.  CRP levels returned to baseline only in this group.  
Creatine Kinase, a marker of muscle breakdown or damage was also blunted in the RhodioLife supplemented subjects
1. Exhausting exercise increased both CRP and CK levels in all subjects, but the rise in CRP was less pronounced at 5 hours for subjects consuming Rhodiolife.  CRP returned to pre-test levels only in the RhodioLife group.
2. Similarly, elevated CK levels remained high 5 days post-test for both placebo and control groups but was significantly lower in the group supplemented with RhodioLife.

CLINICAL HIGHLIGHTS

Clinical Study: Rhodiolife increases physical working capacity

Rhodiolife Time to Exhaustion chart and image

In this animal study, the effects of two different Rhodiola extracts were studied versus placebo on physical performance and muscle health during exhaustive swimming twice daily for 6 days. Subjects with Rhodiolife were able to swim almost 25% longer than control or R. crenulata supplemented rats. The effects of R. rosea extract are due to the presence of rosavins and/or their complex with other compounds. Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of Extracts from Rhodiola Rosea and Rhodiola Crenulata (Crassulaceae) Roots on ATP Content in Mitochondria of Skeletal Muscles. Bull Expo Biol Med. 2003;136(6):585–7.

 

GET THE RESULTS

Rhodiolife Time to Exhaustion chart and image

Clinical Study: Rhodiolife supports muscle during exercise

Rhodiolife C-Reactive Protein chart and image-1

Untrained human volunteers (3 groups) were supplemented 30 days prior and 6 days after exhausting physical exercise using bicycle ergometer with: placebo (340 mg twice/day), Rhodiola rosea (RhodioLife, 340 mg twice/day) and control (no treatment) A less pronounced rise in the inflammatory marker C-reactive protein was observed in the RhodioLife supplemented subjects.  Creatine Kinase, a marker of muscle breakdown or damage was also blunted in the RhodioLife supplemented subjects. Abidov, M & Grachev, S & Seifulla, R & Ziegenfuss, Tim. (2004) Bulletin of Experimental Biology and Medicine, 138. 63-4. 10.1023/B:BEBM.0000046940.45382.53.

 

GET THE RESULTS

Rhodiolife C-Reactive Protein chart and image-1

Clinical Study: Rhodiolife may reduce occasional anxiety

Rhodiolife Reduces Anxiety chart and image

In this small, pilot study, 10 participants with DSM-IV diagnosis of generalized anxiety disorder were supplemented with Rhodiolife for 10 weeks. Several assessments to clinically evaluate symptoms at baseline and following supplementation were used. Daily Rhodiolife consumption decreased ratings on scales of anxiety (HAM-A) and depression (HAM-D). (p=0.001). Self-rated scores on FDADS also significantly decreased (p=0.043). Bystritsky A, Kerwin L, Feusner JD. J Altern Complement Med 2008;14(2):175–80. 

 

GET THE RESULTS

Rhodiolife Reduces Anxiety chart and image
ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

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ACTIVE NUTRITION

Rhodiolife supports sustained energy and promotes faster recovery.

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IMMUNE HEALTH

Rhodiolife supports healthy biological responses necessary for healthy immune, cardiopulmonary and endocrine systems.

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COGNITIVE AND MOOD SUPPORT

Studies have shown that Rhodiola rosea can impact anxiety, stress, cognition and other mood symptoms.

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E-SPORTS

Gamers are looking for enhanced cognitive support as well as the ability to play for many hours in a row. Rhodiolife can help!

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INNOVATIVE BEVERAGES

Rhodiolife is available in a water-soluble form. Studies with Rhodiolife and beverage formulations show that it meets industry standards for performance in processing and that color, flavor, and the bioactives content are shelf-stable.

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SPORTS GRADE

In July 2019, we announced the availability of third-party BSCG Certified Drug Free® Rhodiolife. This rigorous testing program established Rhodiolife as the first sports certified Rhodiola on the market.

APPLICATIONS

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CAPSULES

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EFFERVESCENTS

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POWDERS

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STICK PACKS

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TABLETS

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BEVERAGES

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CHEWS

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GUMMIES

ORIGIN STORY & INSIGHTS

An ingredient sourced from the top of the world

Rhodiola rosea is a hardy plant well suited to the cold climate and high altitudes where it grows and is now farmed. The plants used to make Rhodiolife grow in the Altai Mountains of Central Asia. Rhodiola rosea has a tradition of use that dates back centuries.

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A true adaptogen

Rhodiola is a true adaptogen. Originally coined by Dr. Nikolai Lazarev in 1969, the term “adaptogen” refers to a substance that increases non-specific resistance to stimuli potentially harmful to the organism and stress.

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A foremost rhodiola expert

Plant biochemist Dr. Zakir Ramazanov, who was a founding partner of Nektium Pharma, was one of the first to bring Rhodiola rosea to the attention of the English-speaking world and promoted it through his extensive research on its health benefits, starting as early as 1979.

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High quality, effective, most trusted

Launched 25 years ago, the Rhodiolife brand has earned a reputation as a high-quality and effective adaptogenic botanical extract. The ingredient is the subject of groundbreaking ID assessment and sustainability programs.

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The industry’s most rigorous identity and sustainability programs

When it comes to Rhodiola rosea, identity and sustainability matter to your customers. We deliver on both.

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SUSTAINABILITY

rhodiolife-insights-the-move-to-cultivationThe Move to Cultivation and Compliance

 

Rhodiolife is the subject of one of the industry’s first commercial scale cultivation programs for Rhodiola rosea roots as source materials for its extracts. The result of more than a decade of effort, the project has achieved a physical and phytochemical profile identical to previously supplied wildcrafted material. The new cultivated material is grown not by seeds but by vegetative propagation with root rhizomes – a technique that is faster, more dependable and, crucially, ensures that the molecular composition of the cultivated Rhodiola rosea is identical to the wild-grown plant. Nektium has put into place a Quality Assurance system that monitors Good Agricultural and Collection Practices (GACPs) governing rules of production, harvesting, storage, and record keeping. These are accompanied by training programs and traceability and recall plans. Manually harvested, the Rhodiola roots are transported to Nektium’s facilities in the Canary Islands for further processing. Rhodiolife has also been certified non-GMO by the Non-GMO Verification Project.

 

In 2023, Rhodiolife became the first CITES compliant Rhodiola marketed in North America. In November 2022 CITES – the Convention on International Trade in Endangered Species of Flora and Fauna – approved a proposal to add Rhodiola spp. to Appendix II. This is a list of species that are subject to controls in international trade. Today, PLT has CITES-compliant Rhodiolife available for our customers. The expertise we have developed in this area will ensure we have adequate supplies of this material, and our customers can rest easy that the documentation is handled,

 

Rhodiolife is a standardized extract of Rhodiola rosea – grown in the mountainous territory near the Arctic Circle. It is considered a true adaptogen. Only Rhodiolife’s unique “fingerprint” composition consistently provides the spectrum of compounds found in the root of the plant that are responsible for its biological activity – including rosavin, rosarin, rosin and salidroside. With Rhodiolife, not only is the percentage of the primary actives the same as the root, but so is the ratio of actives. This is not the case with many other Rhodiola rosea ingredients on the market.

IDENTITY & QUALITY YOU CAN TRUST

Reaching New Heights in Rhodiola rosea Quality Assurance

The Nektium ID assessment program

Nektium’s Quality Assurance team conducts multiple identity tests on every batch of Rhodiolife, including macroscopic and sensorial analysis, the development of chromatographic profiles and independent DNA barcode analysis to ensure the authenticity of the raw material. A gentle extraction process is used to unlock the active ingredients while preserving the natural phytochemical profile of the root. The material is then standardized to provide precise levels of bioactive compounds. The resulting HPLC ‘fingerprint’ of the Rhodiolife extract is consistent from batch to batch and matches with that of the native root.

 

This approach offers greater peace of mind around authenticity, which is especially important when adulteration is suspected. Recently, the American Botanical Council’s. Nektium’s Quality Assurance team conducts multiple identity tests on every batch of Rhodiolife, including macroscopic and sensorial analysis, the development of chromatographic profiles and independent DNA barcode analysis to ensure the authenticity of the raw material. A gentle extraction process is used to unlock the active ingredients while preserving the natural phytochemical profile of the root. The material is then standardized to provide precise levels of bioactive compounds. The resulting HPLC ‘fingerprint’ of the Rhodiolife extract is consistent from batch to batch and matches with that of the native root.

 

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  Exclusively manufactured by Nektium, Spain.

 

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“The global demand for Rhodiola rosea has rapidly increased, which has led to shortages of authentic material. Most harvesting comes from alpine regions and forests, where supplies can be depleted quickly without replanting and sustainability efforts. I applaud PLT and Nektium for taking the initiative to develop a sustainable supply. Rhodiolife may well be the most sustainable Rhodiola rosea on the market today.”

Trish Flaster CEO & Founder of Botanical Liaisons
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RESOURCES

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Rhodiolife® Rhodiola rosea Product Sheet
August 22, 2022
Behind every ingredient solution is an even better story, download the product sheet to learn more.
Industry NewsSales Collateral
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Rhodiolife®: Back to the Roots Whitepaper
August 22, 2022
Learn how a cultivation program for Rhodiola improves sustainability and supply assurance.
Industry NewsSales Collateral
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Whole Foods Magazine: PLT Health Solutions Releases Water-Soluble Rhodiolife 28686E9C-0345-47E1-B5C6-FB030592A87D
December 1, 2022
PLT Health Solutions, Inc., will begin offering its Rhodiolife Rhodiola rosea ingredient in a water-soluble form, intended for use in beverages. PLT shared that work on developing this product form was completed by PLT innovation partner Nektium Pharma.
Industry NewsIndustry News
read more
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PLT Will Introduce Cultivated-Sourced Rhodiola rosea Ingredient into the North American Market
September 12, 2022
Innovative approach to root cultivation for Rhodiolife® ingredient will assure availability of supply and improve sustainability
Industry NewsPress Releases
read more
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PLT Introduces Water-Soluble Rhodiola rosea Ingredient into the North American Market
November 28, 2022
New form of Rhodiolife® will expand the range of delivery systems for this adaptogen ingredient
Industry NewsPress Releases
read more
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PLTNEXT Adaptogens Infographic – Rhodiolife®
June 29, 2021
ADAPTOGENS MAKING THEIR MARK: Consumers are more in touch with their mental and emotional well-being than ever before - particularly millenials. They're also looking for new solutions. Download our infographic to learn more!
Industry NewsSales Collateral
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PLT Health Solutions Rhodiolife® Rhodiola Rosea is Verified Non-GMO by the Non-GMO Project
August 29, 2023

PLT Health Solutions, Inc. announced that it has received non-GMO verification from the Non-GMO Project company for its Rhodiolife® Rhodiola rosea ingredient. The verification covers raw materials, manufacturing processes and logistics.

Industry NewsPress Releases
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PLT Offering First CITES-Compliant Rhodiola rosea in North America
April 11, 2023

PLT Health Solutions, Inc announced that it has begun offering CITES-compliant Rhodiolife® Rhodiola rosea in North America. This new development will assure its Rhodiola customers a secure supply of a premium, highly sustainable product that meets all regulatory requirements. 

Industry NewsPress Releases
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PLT to Offer First Third-Party Certified Sports Grade of Rhodiola rosea in U.S. Market
July 30, 2019
BSCG Certified Drug Free® Program Covers 483 Drugs in Total and 272 Drugs Banned in Sports
Industry NewsPress Releases
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Botanical Liaisons and NaturPro Scientific Complete Independent Authentication of Rhodiolife® Rhodiola rosea Ingredient
October 26, 2017
Ingredient Verification Program Motivated by Concerns Raised by Newly Published American Botanical Council Adulterants Bulletin
Industry NewsPress Releases
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Nutraceutical Business Review: PLT plans cultivated-sourced Rhodiola rosea ingredient launch 28686E9C-0345-47E1-B5C6-FB030592A87D
September 13th, 2022
The cultivation programme, developed by PLT innovation partner Nektium Pharma, is the result of more than a decade of effort focused on achieving a physical and phytochemical profile identical to previously supplied wildcrafted material.
Industry NewsIndustry News
read more
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Nutraceuticals World: PLT to Introduce Cultivated Rhodiola Rosea Ingredient in North America 28686E9C-0345-47E1-B5C6-FB030592A87D
September 13th, 2022
PLT Health Solutions will begin selling its Rhodiolife Rhodiola rosea ingredient made from a cultivated source of root materials.
Industry NewsIndustry News
read more
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Nutraceuticals World: PLT Launches Water-Soluble Form of Rhodiola Extract 28686E9C-0345-47E1-B5C6-FB030592A87D
November 28th, 2022
PLT Health Solutions has launched a water-soluble form of its Rhodiolife Rhodiola rosea ingredient in North America, in partnership with Spanish ingredient supplier Nektium Pharma.
Industry NewsIndustry News
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Food Ingredients First: PLT unveils water-soluble Rhodiola rosea amid adaptogen expansion 28686E9C-0345-47E1-B5C6-FB030592A87D
November 29th, 2022
PLT Health Solutions has begun offering its Rhodiolife Rhodiola rosea ingredient in a water-soluble form to US markets. According to the company, this has the potential to dramatically expand the types of consumer products into which it can be formulated, tapping the consumer trend for new and more convenient delivery systems.
Industry NewsIndustry News
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